Projekte der zweiten Förderphase
Im Rahmen des Leibniz-WissenschaftsCampus InterACt werden verschiedene Projekte zur Thematik „Integrative Analyse von Pathogen-induzierten Kompartimenten“ bearbeitet. Diese sind typischerweise als Zusammenarbeit verschiedener lokaler Arbeitsgruppen unter Vernetzung verschiedener Kernkompetenzen konzipiert. Nachfolgend sind die Projekte der zwei Förderphasen angegeben.
Comprehensive proteomic analysis of human cytomegalovirus replication compartments
Structural-functional characterization of the adenoviral DNA binding protein, a key player in viral replication center formation, viral genome replication and production of viral progeny
Membrane dynamics during rhoptry secretion of the malaria parasite
Herpesvirus genome injection at nuclear core complexes
Formation and dynamics of latent herpesvirus episome compartments
Organization of intracellular membrane in Mycobacteria infected cells
Selective replication of viral genomes through nucleated phase separation
The role of lipid droplet biogenesis and metabolism in mycobacterial and viral infections
Dynamic changes of the interactions during transition from viral genome replication to RNP recruitment and budding in Lassa virus infection
Deciphering the multiple roles of Dengue virus non-structural protein 1 in different intracellular compartments
Employing bacteriophages as a combat tool against pathogenic multispecies biofilms
Spatially-resolved bystander effects in viral infections
Projekte der ersten Förderphase
Herpesvirus genome injection at nuclear core complexes
funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)
Intracellular membrane organization in Mycobacterium infected cells
Lipid Droplets in infection
Viral replication compartments as phase-separated intranuclear domains
funded by the LIV Strategic Incentive Programme
Mechanisms of nucleic acid-protein interactions in viral particle assembly
funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)
Flexibility of viral induced nuclear egress coat
Disassembly of the inner membrane complex of Plasmodium falciparum
funded by the CSSB Cooperation and Integration Fund
Dynamics and function of infection compartments and defense-induced cellular re-organizations in plant cells
funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)
Phage spread shaping nanostructures of biofilms
Computational modelling of virus capsid formation
funded by the BWFGB as part of the Center for Data and Computing in Natural Science (CDCS) - Cross Disciplinary Lab 3
Integrative analysis of biomacromolecular interactions
funded by the BWFGB as part of the Center for Data and Computing in Natural Science (CDCS) - Cross Disciplinary Lab 3
Transport form and interactome of plant RNA viruses
funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)
Peroxisome-mediated neutralization of antiviral defense strategies
funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)
Virus-host interactions essential for Lassa virus genome replication and transcription
funded by the DFG
Spatiotemporal coordination of herpesvirus secondary envelopment
funded by Wellcome Trust