Research Groups and Infrastructures
The Leibniz ScienceCampus InterACt connects the various research groups and infrastructures in the Hamburg Metropolitan region on the topic "Integrative Analysis of pathogen-induced Compartments". The research groups and infrastructures involved in the network and their research contributions to InterACt are listed below.
Computational Systems Biology
Prof. Dr. Jan Baumbach
Universität Hamburg, Department of Informatics, ZBH - Center for Bioinformatics
Research interests and expertise
Bioinformatics | Computational Biology | Systems Medicine | Network Medicine | Biomarker Discovery & Validation | Precision Medicine | Computational Biotechnology | Big Data Analytics | Machine Learning | Combinatorial Optimization | Privacy by Design
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Structural biology of infection and inflammation, Crystallography
Prof. Dr. Christian Betzel
Universität Hamburg, Department of Chemistry
Research interests and expertise
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Quantitative Virology
Prof. Dr. Jens Bernhard Bosse
Hannover Medical School, Institute of Virology, RESIST Cluster of Excellence | Centre of Structural Systems Biology | Leibniz Institute of Virology, RESIST guest group
Research interests and expertise
spatiotemporal control of virus morphogenesis| dynamics and kinetics of molecular machines| live-cell Imaging| light-sheet microscopy| CLEM
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Virus-Host Interaction
Prof. Dr. Wolfram Brune
Leibniz Institute of Virology | Universität Hamburg, Department of Chemistry
Research interests and expertise
virus-host interaction | herpesvirus | cytomegalovirus | replication compartments | cell death | apoptosis | necroptosis | pyroptosis | autophagy | macrophage | innate immunity | signaling | inflammatory cytokines | interferon | ER stress | unfolded protein response | UPR | cell fusion | syncytium | antivirals
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Viral Transformation
Prof. Dr. Thomas Dobner
Leibniz Institute of Virology | Universität Hamburg, Department of Biology
Research interests and expertise
viral oncogenesis | intrinsic immunity | SUMOylation | nuclear domains | viral replication compartments | antiviral targets
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Molecular and Diagnostic Virology
Prof. Dr. Nicole Fischer
UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF, Institute for Medical MIcROBIOLOGY, Virology and Hygiene
Research interests and expertise
Virus-host interactions | human polyomaviruses | viral oncogenesis | viral persistence | viral gene expression and compartments | next generation sequencing | antivirals (polyomaviruses) | organoid technology | genomics | epigenetics
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Cell Biology of Human Parasites
Prof. Dr. Tim Gilberger
Bernhard Nocht Institute for Tropical Medicine| Centre of Structural Systems Biology | Universität Hamburg, Department of Biology
Research interests and expertise
cell biology of human parasites | malaria | proliferation strategies in erythrocytes | immunevasion | pathogenicity factors | dynamic of intracellular compartments | protein networks | Post-translational modifications | structure-function analysis | reverse genetics | phenotyping | live and high-resolution microscopy
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Structural Cell Biology of Viruses
Prof. Dr. Kay Grünewald
Leibniz Institute of Virology | Centre of Structural Systems Biology | Universität Hamburg, Department of Chemistry
Research interests and expertise
structural cell biology | virus-host interactions (herpes-, adeno- and retroviruses) | protein-protein interaction networks | integrative structural biology | cryo electron microscopy/tomography | correlative cryo microscopy | image analysis and data processing | molecular dynamics and visualization
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Research interests and expertise
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Biophysics
Prof. Dr. Thomas Gutsmann
Research Center Borstel, Leibniz Lung Center
Research interests and expertise
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Research interests and expertise
virus-host interactions | Hepatitis C virus | flaviviruses | lipid droplets | lipid metabolism | organelle interactions | live cell microscopy | electron microscopy | endogenous retroelements
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Molecular Plant Physiology
Prof. Dr. Stefan Hoth
Universität Hamburg, Department of Biology
Research interests and expertise
molecular biology, biochemistry and cell biology of plant autoimmunity and defense | function of plasma membrane-associated Ubiquitin ligases in vesicle tethering | meristem function and DNA damage response in plant development
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RNA Biochemsitry and Molecular Biology
Prof. Dr. Zoya Ignatova
Universität Hamburg, Department of Chemistry
Research interests and expertise
protein translation and folding | translation control | systems biology of translation | translation-related pathologies and infections | tissue-specificity of translation and various pathologies | RNA | ribosomes | aging
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Experimental Cryo-Photonics
Prof. Dr. Rainer Kaufmann
Centre for Structural Systems Biology CSSB | Universität Hamburg, Department of Physics
Research interests and expertise
cryo super-resolution fluorescence microscopy | cryo-CLEM | in-resin super-resolution CLEM | photo-physics under cryo conditions | optical engineering |cryogenic engineering
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Molecular Plant Genetics
Prof. Dr. Julia Kehr
Universität Hamburg, Department of Biology
Research interests and expertise
plants| phloem| long distance transport| signaling| RNA binding proteins| ribonucleoprotein complexes| virus infection| mass spectrometry
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Integrative modelling of infection cycles
Dr. Jan Kosinski
Centre of Structural Systems Biology CSSB | EMBL
Research interests and expertise
infection cycles of pathogens | host-pathogen interactions | macromolecular complexes | influenza A virus | nuclear pore complexes | proteomics | imaging | computational modeling
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Functional protein fibrils
Prof. Dr. Meytal Landau
CENTRE OF STRUCTURAL SYSTEMS BIOLOGY CSSB | DEUTSCHES ELEKTRONEN-SYNCHROTRON | UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF
Research interests and expertise
Structural biology | Amyloid fibrils | Protein self-assembly | X-ray crystallography | Cryo electron microscopy | Structural bioinformatics | Virulent and antimicrobial fibrils | Microbes and neurodegeneration | Protein-membrane interactions
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Evolutionary Immunogenomics
Prof. Dr. Tobias Lenz
Universität Hamburg, Department of Biology
Research interests and expertise
Evolutionary genetics and genomics | Host-pathogen coevolution | antigen presentation and recognition | bioinformatics
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Cellular microbiology
Prof. Dr. Stefan Linder
UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF
Research interests and expertise
Phagocytosis and intracellular processing of bacteria | Spirochetes (Borrelia burgdorferi) | Primary human macrophages | Cytoskeleton (actin, tubulin) | Intracellular transport | Membrane dynamics | Live cell and high resolution microscopy
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Pharmaceutical and Medicinal Chemistry
Prof. Dr. Wolfgang Maison
Universität Hamburg, Department of Chemistry
Research interests and expertise
organic synthesis and coordination chemistry | Tumor targeting (prostate cancer); metal-based reagents for MRI, PET and SPECT | antibacterial surfaces (metals and plastics) for implant medicine and clinical hygiene | development of chemical corrosion inhibitors | siderophore analogues for biomedical applications
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Organic Chemistry, Medicinal Chemistry and Chemical Biology
Prof. Dr. Chris Meier
Universität Hamburg, Department of Chemistry
Research interests and expertise
organic and medicinal chemistry | chemical Biology | antiviral drug discovery (Virus families: Bunya viruses, Retroviruses, Hepatitis, filo-virues) | small molecule inhibitors | nucleos(t)die chemistry | pronucleotides | lipophilic adenosine second messengers | RNA-polymerases | structure biology with polymerases and the enzyme DHODH
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Experimental Biophysics
Prof. Dr. Arwen Pearson
Universität Hamburg, Fachbereich Physik | Center for Ultrafast Imaging CUI | Center for Free-electron Science CFEL
Research interests and expertise
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Computational Molecular Design
Prof. Dr. Matthias Rarey
Universität Hamburg, Department of Informatics, ZBH - Center for Bioinformatics
Research interests and expertise
cheminformatics | structure-based molecular design | structuralbioinformatics | development of computational methods for life science | visual analytics of chemical data | machine learning and data mining of chemical structures and molecular complexes | navigation in large chemical spaces
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Microscopy and Image Analysis technology platform
Dr. Rudolph Reimer
Leibniz Institute of Virology
Research interests and expertise
confocal microscopy | TIRF | single molecule imaging techniques | functional imaging of living cells | 3D electron microscopy | TEM / SEM | correlative light and electron microscopy | (cryo)-ultramicrotomy | microtomy | cryo-preparation | histology | negative staining of particles | image analysis
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Plant Biochemistry and Infection Biology
Prof. Dr. Sigrun Reumann
Universität Hamburg, Department of Biology
Research interests and expertise
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Structural Virology
Dr. Maria Rosenthal
Bernhard Nocht Institute for Tropical Medicine
Research interests and expertise
bunyaviruses | Lassa virus | Rift Valley fever virus | genome replication and transcription | molecular mechanism | L protein | viral polymerase | protein-protein interaction | protein-RNA interaction | virus-host interaction | functional assays | structural biology | biochemistry | molecular biology | reverse genetics
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Research interests and expertise
Arboviruses | RNA viruses| Flaviviruses| Bottom-up Mass-spectrometry| virus replication| assembly and release| cellular determinants of plus-strand RNA virus replication| Systems Biology| Proteomics| Post-translational modifications| mosquitoes cell-virus interactions
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Cellular Microbiology
Prof. Dr. Ulrich Schaible
Research Center Borstel, Leibniz Lung Center
Research interests and expertise
host-pathogen interactions in tuberculosis | mycobacterial intracellular niche as determinant for transmission, immunity, pathogenesis, drug efficacy | translational research on host-directed-therapy and nanocarrier-based drug delivery | lung microbiota, stenotrophomonas maltophilia
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Research interests and expertise
analysis and modelling of pathogen-related transport processes in biological systems | algorithms for the analysis of complex multiscale image data (e.g. live-cell imaging) | machine learning supported feature analysis for biological images | user training, tool development and support for image analysis tasks
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Mass Spectrometric Proteomics
Prof. Dr. Hartmut Schlüter
University Medical Center Hamburg-Eppendorf | Universität Hamburg, Department of Chemistry
Research interests and expertise
differential quantitative mass spectrometry-based proteomics | labeling based quantification: SILAC, TMT | labeling-free quantification: DIA, DDA, SRM | systems biology | protein-protein interactions | pathway analysis | targeted proteomics | mass spectrometric imaging | proteoforms | glycans | glycoproteomics | phosphoproteomics
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Developmental Biology
Prof. Dr. Arp Schnittger
Universität Hamburg, Department of Biology
Research interests and expertise
entry and progression through meiosis | organization of meiotic chromosomes | cell biology of meiocytes | DNA damage response and homologous recombination | live cell imaging
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Multi-User Cryo-EM facility
Dr. Carolin Seuring
CENTRE OF STRUCTURAL SYSTEMS BIOLOGY CSSB | Universität Hamburg
Research interests and expertise
cryo electron-microscopy | host-pathogen interaction | molecular and cellular electron cryo-tomography | Cryo-SPA | FIB / SEM | correlative light and electron microscopy | cryo-specimen preparation | negative staining of particles | image analysis | training | method development
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Molecular and Structural Microbiology
Prof. Dr. Holger Sondermann
CENTRE OF STRUCTURAL SYSTEMS BIOLOGY CSSB | Deutsches Elektronen-Synchrotron | Christian-Albrechts-Universität, Kiel
Research interests and expertise
Structural biology | bacteria | bacterial biofilms | cell signaling | protein biochemistry and biophysics | structure-function studies
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AG Spielmann
Dr. Tobias Spielmann
BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE
Research interests and expertise
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Microbiology and Biotechnology
Prof. Dr. Wolgang Streit
Universität Hamburg, Department of Biology
Research interests and expertise
functional metagenomics in the search for new biocatalysts | microbial plastics degradadtion | marine biotechnology | microbial biofilms: analytics, architecture and omics | cell-cell communication in bacteria
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Microscopy and Image Analysis technology platform
Dr. Roland Thünauer
Leibniz Institute of Virology
Research interests and expertise
confocal microscopy | TIRF | single molecule imaging techniques | functional imaging of living cells | 3D electron microscopy | TEM / SEM | correlative light and electron microscopy | (cryo)-ultramicrotomy | microtomy | cryo-preparation | histology | negative staining of particles | image analysis
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Integrative Virology
Prof. Dr. Maya Topf
CENTRE OF STRUCTURAL SYSTEMS BIOLOGY CSSB | Leibniz Institute of Virology | University Medical Center Hamburg-Eppendorf
Research interests and expertise
Computational structural biology | macromolecular assemblies | viral protein interaction networks | cryo electron microscopy | cryo EM validation | image processing | density fitting | integrative modelling | molecular simulations | molecular docking
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Mathematics and Computational Virology
Prof. Dr. Reidun Twarock
University of York
Research interests and expertise
mathematical and computational modelling of virus structure, assembly mechanisms and evolution | intra- and inter-cellular models of infection dynamics | bioinformatics of viral genomes | antiviral therapy | virus nanotechnology
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Dynamic of Viral Structures
Dr. Charlotte Uetrecht
Centre of Structural Systems Biology | European XFEL GmbH | Leibniz Institute of Virology | University of Siegen
Research interests and expertise
viral capsid assembly as well as viral replication complexes and the underlying protein structural dynamics | development of native mass spectrometry for higher resolution structural proteomics and single particle imaging at X-ray free-electron lasers | hydrogen/deuterium exchange mass spectrometry
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Cell Biology of RNA Viruses
Dr. Gabrielle Vieyres
Leibniz Institute of Virology
Research interests and expertise
RNA viruses| Hepatitis C virus| lipid droplets| virus replication| assembly and release| cell determinants of plus-strand RNA virus replication| innate immunity| cell biology| Confocal microscopy| automatized image analysis
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Protein production core facility
Dr. Susanne Witt
CENTRE OF STRUCTURAL SYSTEMS BIOLOGY CSSB | UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF
Research interests and expertise
Cloning and mutagenesis | R2/S2 cultivation of prokaryotic and eukaryotic cells | Transformation of prokaryotes | Transfection of eukaryotes | High-throughput heterologous expression screening in plate format | Recombinant expression in E. coli, insect cells and mammalian cells | Cell harvest and cell lysis | Ultracentrifugation and cell membrane isolation | Protein purification | Development, optimisation & automation of protein purification protocols | Biophysical & biochemical characterisation | E. coli strain collection | Expression vector collection | NEB freezer
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Infection biology
N.N.
Universität Hamburg, Department of Biology
Research interests and expertise
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